Full Schedule
| Matchup | Week | Date/Time | Spread | Total | Result |
|---|---|---|---|---|---|
| CLEvs Cleveland Browns | 1 | Sun, Sep 13, 12:00 PM | JAX -8.5 -1 | 40.5 | W 34–10 |
| DENat Denver Broncos | 2 | Sun, Sep 20, 3:05 PM | JAX +3 -0.5 | 45.5 +2 | — |
| NEvs New England Patriots | 3 | Sun, Sep 27, 12:00 PM | — | — | — |
| CINat Cincinnati Bengals | 4 | Sun, Oct 4, 12:00 PM | JAX +2.5 | 51.5 | — |
| PHIvs Philadelphia Eagles | 5 | Sun, Oct 11, 8:30 AM | JAX +1.5 | 45.5 | — |
| HOUvs Houston Texans | 6 | Sun, Oct 18, 8:30 AM | JAX -1.5 | 42.5 | — |
| INDvs Indianapolis Colts | 8 | Sun, Nov 1, 12:00 PM | JAX -4.5 | 49.5 | — |
| BALat Baltimore Ravens | 9 | Thu, Nov 5, 7:15 PM | JAX +4.5 | 49.5 | — |
| TENat Tennessee Titans | 10 | Sun, Nov 15, 12:00 PM | JAX -2.5 | 45.5 | — |
| NYGat New York Giants | 11 | Sun, Nov 22, 12:00 PM | JAX -1.5 | 46.5 | — |
| TENvs Tennessee Titans | 12 | Sun, Nov 29, 3:05 PM | JAX -5.5 | 45.5 | — |
| CHIat Chicago Bears | 13 | Sun, Dec 6, 12:00 PM | JAX +3 | 47.5 | — |
| PITvs Pittsburgh Steelers | 14 | Mon, Dec 14, 7:15 PM | JAX -3 | 44.5 | — |
| HOUat Houston Texans | 15 | Sun, Dec 20, 12:00 PM | JAX +3 | 43.5 | — |
| DALat Dallas Cowboys | 16 | Sun, Dec 27, 7:20 PM | JAX +3 | 51.5 | — |
| WASvs Washington Commanders | 17 | Sat, Jan 2, 11:00 PM | JAX -3.5 | 48.5 | — |
| INDat Indianapolis Colts | 18 | Sat, Jan 9, 11:00 PM | JAX +1.5 | 46.5 | — |
Division
The Jaguars play in the AFC South, which means six of their games every season come against these three clubs.