Full Schedule
| Matchup | Week | Date/Time | Spread | Total | Result |
|---|---|---|---|---|---|
| NOvs New Orleans Saints | 1 | Sun, Sep 13, 12:00 PM | DET -7 | 49.5 +1 | W 31–30 |
| BUFat Buffalo Bills | 2 | Thu, Sep 17, 7:15 PM | DET +5.5 -2.5 | 54.5 +2 | L 31–41 |
| NYJvs New York Jets | 3 | Sun, Sep 27, 12:00 PM | DET -7 +2.5 | 48.5 +3 | — |
| CARat Carolina Panthers | 4 | Sun, Oct 4, 7:20 PM | DET -3 | 47.5 | — |
| ARIat Arizona Cardinals | 5 | Sun, Oct 11, 3:25 PM | DET -8.5 | 48.5 | — |
| GBvs Green Bay Packers | 7 | Sun, Oct 25, 3:25 PM | DET -2.5 | 50.5 | — |
| MINvs Minnesota Vikings | 8 | Sun, Nov 1, 12:00 PM | DET -4.5 | 47.5 | — |
| MIAat Miami Dolphins | 9 | Sun, Nov 8, 12:00 PM | DET -6.5 | 47.5 | — |
| NEvs New England Patriots | 10 | Sun, Nov 15, 8:30 AM | DET -1.5 | 48.5 | — |
| TBvs Tampa Bay Buccaneers | 11 | Sun, Nov 22, 12:00 PM | DET -4.5 | 49.5 | — |
| CHIvs Chicago Bears | 12 | Thu, Nov 26, 12:00 PM | DET -2.5 | 52.5 | — |
| ATLat Atlanta Falcons | 13 | Sun, Dec 6, 12:00 PM | DET -3.5 | 48.5 | — |
| TENvs Tennessee Titans | 14 | Sun, Dec 13, 12:00 PM | DET -7.5 | 47.5 | — |
| MINat Minnesota Vikings | 15 | Sun, Dec 20, 7:20 PM | DET -1.5 | 46.5 | — |
| NYGvs New York Giants | 16 | Mon, Dec 28, 7:15 PM | DET -4.5 | 49.5 | — |
| CHIat Chicago Bears | 17 | Sun, Jan 3, 3:25 PM | DET +1.5 | 49.5 | — |
| GBat Green Bay Packers | 18 | Sat, Jan 9, 11:00 PM | DET +2.5 | 47.5 | — |
Division
The Lions play in the NFC North, which means six of their games every season come against these three clubs.