Full Schedule
| Matchup | Week | Date/Time | Spread | Total | Result |
|---|---|---|---|---|---|
| LACat Los Angeles Chargers | 1 | Sun, Sep 13, 3:25 PM | ARI +8.5 +2 | 47.5 +1 | W 26–14 |
| SEAvs Seattle Seahawks | 2 | Sun, Sep 20, 3:25 PM | ARI +3.5 -6.5 | 40.5 -4 | L 7–31 |
| SFat San Francisco 49ers | 3 | Sun, Sep 27, 3:05 PM | ARI +7.5 +4 | 48.5 +2 | L 30–36 |
| NYGat New York Giants | 4 | Sun, Oct 4, 12:00 PM | ARI -2.5 +9.5 | 43.5 -2 | L 24–36 |
| DETvs Detroit Lions | 5 | Sun, Oct 11, 3:25 PM | ARI +5.5 -3 | 55.5 +7 | L 21–45 |
| LARat Los Angeles Rams | 6 | Sun, Oct 18, 3:05 PM | ARI +12.5 +1 | 51.5 +4 | W 18–16 |
| DENvs Denver Broncos | 7 | Sun, Oct 25, 3:05 PM | ARI +4.5 -3 | 44.5 +1 | L 16–30 |
| DALat Dallas Cowboys | 8 | Sun, Nov 1, 12:00 PM | ARI +7 +3.5 | 54.5 +7 | W 33–30 |
| SEAat Seattle Seahawks | 9 | Sun, Nov 8, 3:25 PM | ARI +12.5 +1 | 41.5 -4 | — |
| LARvs Los Angeles Rams | 10 | Sun, Nov 15, 3:05 PM | ARI +7.5 -3 | 47.5 | — |
| KCat Kansas City Chiefs | 11 | Sun, Nov 22, 12:00 PM | — | — | — |
| WASvs Washington Commanders | 12 | Sun, Nov 29, 3:25 PM | — | — | — |
| PHIvs Philadelphia Eagles | 13 | Sun, Dec 6, 3:05 PM | — | — | — |
| NYJvs New York Jets | 15 | Sun, Dec 20, 3:05 PM | — -3 | — | — |
| NOat New Orleans Saints | 16 | Sun, Dec 27, 12:00 PM | — | — | — |
| LVvs Las Vegas Raiders | 17 | Sun, Jan 3, 3:05 PM | — | — | — |
| SFvs San Francisco 49ers | 18 | Sat, Jan 9, 11:00 PM | — | — | — |
Division
The Cardinals play in the NFC West, which means six of their games every season come against these three clubs.